Atypical femoral fractures and bisphosphonate use.
نویسندگان
چکیده
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منابع مشابه
Increasing occurrence of atypical femoral fractures associated with bisphosphonate use.
BACKGROUND Current evidence suggests that there is an association between bisphosphonate therapy and atypical femoral fractures, but the extent of this risk remains unclear. METHODS Between 1999 and 2010, a total of 477 patients 50 years and older were hospitalized with a subtrochanteric or femoral shaft fracture at a single university medical center. Admission radiographs and medical and tre...
متن کاملWhat do we know about atypical femoral fractures? Insights and enigmas.
Although the existence of atypical femoral fractures is well established and bisphosphonate therapy is thought to be a major risk factor, the underlying mechanisms are poorly understood. Epidemiological data show that atypical femoral fractures account for only a small proportion of diaphyseal subtrochanteric femoral fractures, being about 100 times less common than proximal femoral fractures. ...
متن کاملRisk of atypical femoral fracture during and after bisphosphonate use
BACKGROUND AND PURPOSE Use of bisphosphonates in women is associated with higher risk of atypical femoral fractures. The risk in terms of timing of use and type of bisphosphonate, and in men, remains unclear. PATIENTS AND METHODS We reviewed radiographs of 5,342 Swedish women and men aged 55 years or more who had had a fracture of the femoral shaft in the 3-year period 2008-2010 (97% of those...
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CONTEXT An expert opinion perspective on why osteoporosis is underdiagnosed and undertreated. OBJECTIVE To highlight the potential reasons for why osteoporosis is undertreated. DESIGN Literature review from PubMed, Plos One, and Science Direct search engines from 1900-2015 under terms: sub-trochanteric and atypical femur fractures, bisphosphonate clinical trial and bisphosphonate review art...
متن کاملAtypical femoral fractures are a separate entity, characterized by highly specific radiographic features. A comparison of 59 cases and 218 controls.
BACKGROUND Estimations of the risk of bisphosphonate associated atypical femoral fractures vary between different population-based studies, from considerable to neglectable. A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use. METHODS In a pre...
متن کاملRisk of atypical femoral fracture during and after bisphosphonate use Full report of a nationwide study
Risk of atypical femoral fracture during and after bisphosphonate use Full report of a nationwide study, 2015, Open Access-This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. Background and purpose — Use of bisphosphonates in women...
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عنوان ژورنال:
- The New England journal of medicine
دوره 362 19 شماره
صفحات -
تاریخ انتشار 2010